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Science & Hypochlorous Acid Frequently Asked Questions
Below are Frequently Asked Questions (FAQs) from professional users of Puracyn® Plus Professional Formula Wound Irrigation Solution and Puracyn® Plus Professional Formula Antimicrobial Hydrogel. Please select the FAQ topic of interest to you to review those Frequently Asked Questions.
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GOOD REPRINT PRACTICES DISCLAIMER: This section contains scientific questions related to hypochlorous acid. The information is provided based on available scientific literature. While Puracyn Plus Professional Formula contains hypochlorous acid, it should be noted that Puracyn Plus Professional Formula is a formulated medical device that contains many additional components, and its clinical use is strictly limited to the following indications:
Puracyn Plus Professional Formula Wound Irrigation Solution is intended for use by healthcare professionals for cleansing, irrigating, moistening, and debriding to remove wound debris from acute and chronic dermal lesions that are partial or full-thickness wounds such as 1st and 2nd degree burns, stage I-IV pressure injuries, diabetic ulcers, stasis ulcers, abrasions and minor skin irritations, post-surgical wounds, grafted and donor sites, in addition to moistening and lubricating absorbent wound dressings.
Puracyn Plus Professional Formula Antimicrobial Hydrogel is intended for use by healthcare professionals to moisten the wound bed and facilitate the autolytic debridement of acute and chronic dermal lesions, as indicated below. Puracyn Plus Professional Formula Antimicrobial Hydrogel relieves itch and pain associated with dermal irritation, sores, injuries, and ulcers of dermal tissue in addition to moistening and lubricating absorbent wound dressings. Puracyn Plus Professional Formula Antimicrobial Hydrogel is indicated for the management of partial or full-thickness wounds such as 1st and 2nd degree burns, stage I – IV pressure injuries, diabetic and stasis ulcers, abrasions and skin irritations, surgical wounds (donor and graft sites, incisions), trauma wounds, and various dermatoses including atopic dermatitis.
Healthcare professionals are expected to review the FULL content of publications referenced below and make objective assessments on the relevance and appropriateness for a clinical use outside of the approved indications based on their professional training and that of their peers. If it’s helpful, please don’t hesitate to contact us directly through Customer Service at 866-318-3116.
Hypochlorous acid is naturally produced by the body’s immune system.1-2 This molecule can also be synthesized chemically, for example, by electrolysis as in the case of Puracyn Plus Professional Formula. Below is a list of available scientific texts and publications regarding biological function of hypochlorous acid.
- Sakarya S, Gunay N, Karakulak M, Ozturk B, Ertugrut B. Hypochlorous acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Wounds. 2014; 26(12): 342-350
- Weiss SJ, Lampert MB, Test ST. Long-lived oxidants generated by human neutrophils: characterization and bioactivity. Science. 1983; 222: 625-628
- Kleanoff SJ, Myeloperoxidase: contribution to the microbiocidal activity of intact leukocytes. Science. 1970; 169(950): 1095-1097
- Nakae H, Inaba H. Effectiveness of electrolyzed oxidized water irrigation in a burnwound infection model. J. Trauma. 2000; 49(3): 511-512
Hypochlorous acid has been primarily used in wound cleansing solutions as an antimicrobial preservative to inhibit the growth of microorganisms within the product in case of contamination during storage or use. However, additional clinical benefits of products containing hypochlorous acid have been reported. Below is an available scientific publication regarding the clinical use of hypochlorous acid.
Bongiovanni CM. Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU): Experience With 1249 VLUs in 97 Patients. J Am Coll Clin Wound Spec. 2016 Jan 21;6(3):32-7
Hypochlorous acid has also been used as the active ingredient in EPA-approved disinfectants in a broad range of applications including surface sanitization and disinfection needs in hospitals and healthcare facilities.
Hypochlorous acid, being electrically neutral in solution, is significantly more efficacious in killing microorganisms than common bleach solution which is electrically negative in solution. The cell wall of a pathogenic microorganism is negatively charged by nature. The negative charge of a bleach molecule would be repulsed by the cell wall, making it a weak disinfectant. On the other hand, the neutral hypochlorous acid molecule can penetrate the cell wall of pathogenic microorganisms easily, making it a very effective disinfectant. Hypochlorous acid can also penetrate slime layers and protective layers of microorganisms as a result.
For more information about hospital-grade disinfectants, please send your inquiry to: info@skvscientific.com (SKV Scientific, Inc.)